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Pacijentima koji žele da počnu da uzimaju lekove koji imaju klirens kreatinina (CrCl) od 30 mL se generalno savetuje da koriste manju dozu. Ovim pacijentima se preporučuje oko twenty five mg da počnu da koriste, jer bi veća doza potencijalno mogla da izazove dalje zdravstvene probleme.
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